The Guadalajara cartel was one of the earliest drug cartels from Mexico. The cartel was found and led by Miguel Angel Felix Gallardo, and smuggled cocaine and marijuane, among other things, into the United States. The cartel is considered to have practically invented the Mexican drug trade.
The cartel gained notoriety when it tortured and killed American DEA agent Enrique 'Kiki' Camarena in 1985, causing the United States to aggressively pursue the cartel, resulting in the death and imprisonment of several key figures, leading the cartel to disbandment in 1989.
The cartel split into many groups, many of them are still warring as part of the Mexican Drug War as of 2018.