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Amparo Santacruz was the wife of Chepe Santacruz.

Amparo lived in New York City as her husband managed the Cali cartel's operations there under an assumed identity. After an explosion in one of Chepe's labs, journalist Manuel de Dios Unanue revealed her husband's identity. Amparo refused to leave the United States, and told her husband to fix the problem. Despite killing de Dios, Chepe was unable to shake off the police and was forced to leave for Colombia with Amparo.

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